Which RPG has the most jaw-dropping layout?
Oh, see, this one is easy. Eclipse Phase. In my experience, the EP books were the first game books ever to really take advantage of the PDF format, and the idea that these books would likely be looked at on tablets/phones/mobile devices. Not only is the story and the ruleset well laid-out and well-integrated, but the books themselves are carefully and copiously hyperlinked, so that any particular term can be touched/clicked on to take you to that page/definition/example, and then back again to continue on your way.
EP is brilliantly future-minded, especially for a game so immersed in the technofuture of the setting itself. It's immersive just by existing as a fully-indexed and fully-interactive set of documents. I imagine it was a gigantic pain in the ass to build (and rebuild) these books, but to me it's totally worthwhile and I've never appreciated the structure and care of a PDF more than when I peruse the EP books. Posthuman Studios does amazing work. You should check them out!